Effect of Intensive Diabetes Treatment on Cardiovascular Disease in Patients with Type 1 Diabetes
This is an interesting study published in this week's issue of NEJM. Hitherto, we have been concerned mainly about the increased cardiovascular risk in Type 2 diabetics. There are few studies on type 1 diabetics.
Previously, it had been shown that intensive diabetes therapy aimed at achieving near normoglycemia reduces the risk of microvascular and neurologic complications of type 1 diabetes. This study whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease.
It was found that intensive treatment reduced the risk of any cardiovascular disease event by 42% and the risk of nonfatal myocardial infarction, stroke, or death from cardiovascular disease by 57%. The decrease in glycosylated hemoglobin values during the DCCT was significantly associated with most of the positive effects of intensive treatment on the risk of cardiovascular disease. Microalbuminuria and albuminuria were also associated with a significant increase in the risk of cardiovascular disease.
The study concludes that intensive diabetes therapy has long-term beneficial effects on the risk of cardiovascular disease in patients with type 1 diabetes. One more reason for intensive therapy for Type 1 Diabetes!
Previously, it had been shown that intensive diabetes therapy aimed at achieving near normoglycemia reduces the risk of microvascular and neurologic complications of type 1 diabetes. This study whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease.
It was found that intensive treatment reduced the risk of any cardiovascular disease event by 42% and the risk of nonfatal myocardial infarction, stroke, or death from cardiovascular disease by 57%. The decrease in glycosylated hemoglobin values during the DCCT was significantly associated with most of the positive effects of intensive treatment on the risk of cardiovascular disease. Microalbuminuria and albuminuria were also associated with a significant increase in the risk of cardiovascular disease.
The study concludes that intensive diabetes therapy has long-term beneficial effects on the risk of cardiovascular disease in patients with type 1 diabetes. One more reason for intensive therapy for Type 1 Diabetes!
posted by drheart at
6:17 PM
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